Luís Suárez Halty, Maura Dumont Hüttner, Isabel de Oliveira Netto, Thaís Fenker, Tatiana Pasqualini, Berenice Lempek, Adriana Santos, Alessandra Muniz

J Bras Pneumol.2002;28(2):77-83

Mortality due to idiopathic pulmonary fibrosis in the State of Rio Grande do Sul (Brazil)

Mortalidade por fibrose pulmonar idiopática no Rio Grande do Sul

Fabrício Picolli Fortuna, Christiano Perin, Letícia Cunha, Adalberto Sperb Rubin

J Bras Pneumol.2003;29(3):121-124

Prevalence of Streptococcus pneumoniae resistance to penicillin in two hospital from Caxias do Sul

Prevalência de resistência à penicilina do Streptococcus pneumoniae em dois hospitais de Caxias do Sul

Wilson Paloschi Spiandorello, Fernanda Morsch, Franca Stedile Angeli Spiandorello

J Bras Pneumol.2003;29(1):15-20

Drug resistance profile of Mycobacterium tuberculosis in the state of Mato Grosso do Sul, Brazil, 2000-2006

Perfil de resistência de Mycobacterium tuberculosis no estado de Mato Grosso do Sul, 2000-2006

Marli Marques, Eunice Atsuko Totumi Cunha, Antonio Ruffino-Netto, Sonia Maria de Oliveira Andrade

J Bras Pneumol.2010;36(2):224-231

Objective: To determine the drug resistance profile of Mycobacterium tuberculosis in the state of Mato Grosso do Sul, Brazil, between 2000 and 2006. Methods: Descriptive study of reported tuberculosis cases in the Brazilian Case Registry Database. We included only those cases in which M. tuberculosis culture was positive and sensitivity to drugs (rifampicin, isoniazid, streptomycin and ethambutol) was tested. Löwenstein-Jensen and Ogawa-Kudoh solid media were used for cultures, as was an automated liquid medium system. Sensitivity tests were based on the proportion method. Results: Among the 783 cases evaluated, males predominated (69.7%), as did patients in the 20-49 year age bracket (70%), a diagnosis of pulmonary tuberculosis (94.4%) and positive HIV serology (8.6%); 645 (82.4%) were new cases, and 138 (17.6%) had previously been treated. Resistance to at least one drug was found in 143 cases (18.3%). The primary resistance (PR) rate was, respectively, 8.1%, 1.6%, 2.8% and 12.4%, for monoresistance, multidrug resistance (MDR), other patterns of resistance and resistance to at least one drug, whereas the acquired resistance (AR) rate was 14.5%, 20.3%, 10.9% and 45.7%, respectively, and the combined resistance (CR) rate was 9.2%, 4.9%, 4.2% and 18.3%, respectively. In PR, streptomycin was the most common drug, whereas isoniazid was the most common in AR and CR (7.2% and 3.7%, respectively). Conclusions: These high levels of resistance undermine the efforts for tuberculosis control in Mato Grosso do Sul. Acquired MDR was 12.7 times more common than was primary MDR, demonstrating that the previous use of drug therapy is an indicator of resistance. These levels reflect the poor quality of the health care provided to these patients, showing the importance of using the directly observed treatment, short course strategy, as well as the need to perform cultures and sensitivity tests for the early diagnosis of drug resistance.

Keywords: Tuberculosis; Drug resistance, multiple; Mycobacterium tuberculosis.

Asthma and atopy prevalence in a group of students from Porto Alegre, Rio Grande do Sul

Variação na prevalência de asma e atopia em um grupo de escolares de Porto Alegre, Rio Grande do Sul

Renata Wagner Fiore, Adriana Barbieri Comparsi, Cláudia Loss Reck, Jéferson Krawcyk de Oliveira, Karina Brasco Pampanelli, Carlos Cezar Fritscher

J Bras Pneumol.2001;27(5):237-242

Spatial analysis of hospitalizations for pneumonia in the Vale do Paraíba region of Brazil

Análise espacial das internações por pneumonia na região do Vale do Paraíba (SP)

Adriana de Oliveira Mukai, Kátia de Souza Costa Alves, Luiz Fernando Costa Nascimento

J Bras Pneumol.2009;35(8):753-758

Nontuberculous mycobacteria isolated in São José do Rio Preto, Brazil between 1996 and 2005

Isolamento de micobactérias não-tuberculosas em São José do Rio Preto entre 1996 e 2005

Heloisa da Silveira Paro Pedro, Maria Izabel Ferreira Pereira, Maria do Rosário Assad Goloni, Suely Yoko Mizuka Ueki, Erica Chimara

J Bras Pneumol.2008;34(11):950-955

Change in asthma mortality trends in children and adolescents in Rio Grande do Sul: 1970-1998

Mudança da tendência da mortalidade por asma em crianças e adolescentes no Rio Grande do Sul: 1970-1998

José Miguel Chatkin, Jussara Fiterman, Nivalvo Almeida Fonseca, Carlos Cezar Fritscher

J Bras Pneumol.2001;27(2):89-93

Tuberculin skin test: operational research in the state of Mato Grosso do Sul, Brazil

Teste tuberculínico: pesquisa operacional no Mato Grosso do Sul

Sandra Maria do Valle Leone de Oliveira, Antônio Ruffino-Netto, Anamaria Mello Miranda Paniago, Olcinei Alves de Oliveira, Marli Marques, Rivaldo Venâncio da Cunha, Renato Andreotti

J Bras Pneumol.2011;37(5):646-654

Acute pulmonary histoplasmosis in the state of Rio Grande do Sul, Brazil

Histoplasmose pulmonar aguda no Rio Grande do Sul

Gisela Unis, Eliane Wurdig Roesch, Luiz Carlos Severo

J Bras Pneumol.2005;31(1):

Background: Acute pulmonary histoplasmosis is a respiratory infection occurring when an otherwise healthy individual inhales a large quantity of fungal propagules. Length of exposure determines disease severity. An epidemic is influenced by factors affecting the growth and transmission of Histoplasma capsulatum var. capsulatum in nature. Objective: To identify epidemiological and clinical aspects of patients with acute pulmonary histoplasmosis in the state of Rio Grande do Sul (RS) and compare these aspects with those of other cluster outbreaks reported in Brazil. Method: The charts of 212 patients diagnosed with histoplasmosis over a 25-year period (1977-2002) were obtained from the archives of the Laboratório de Micologia from Complexo Hospitalar Santa Casa (Santa Casa Hospital Mycology Laboratory), in the city of Porto Alegre (RS). In reviewing these patient charts, we identified and included in the study cases of acute pulmonary histoplasmosis in which there was a positive culture and/or histopathological findings consistent with the diagnosis. Outbreaks were defined as one confirmed case or positive immunodifusion Histoplasma capsulatum with compatible clinical history. All reported Brazilian outbreaks were reviewed. Results: Of the 212 patient charts reviewed, 18 (8.5%) were selected for inclusion in the study. Among those 18 patients, ages ranged from 8 to 63 years (median, 35.4), and 67% were male. Epidemiological histories were suggestive of the disease in 11 patients (61%). The most common disease type, seen in 17 patients (95%), was primary acute pulmonary histoplasmosis, and there was a predominance of isolated cases. Conclusion: The identification of isolated cases and the presence of cluster outbreaks demonstrate the abundance of H. capsulatum in the soil and, together with the occurrence of all forms of the disease, confirms the assumption that Rio Grande do Sul is a hyperendemic region for histoplasmosis.

Keywords: Key words - Histoplasmosis/epidemiology. Histoplasmosis/diagnostic. Histoplasma. Medical records. Retrospective studies.

Letters to the Editor

Omalizumab: what do we learn from patients in treatment for more than ten years?

Omalizumabe: o que nos ensinam os pacientes com mais de dez anos de uso?

Faradiba Sarquis Serpa1, Joseane Chiabai1,2, Fernanda Lugão Campinhos1, Augusto Sarquis Serpa1, Firmino Braga Neto1

J Bras Pneumol.2020;46(3):e20180352

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