A 68-year-old woman was admitted to the emergency department with sudden dyspnea and chest pain of 3 days’ duration. She had had a domestic accident resulting in closed tibial and fibular fractures 5 days prior. Chest CT showed a filling defect in the left lower-lobe pulmonary artery with fatty attenuation, and a ground-glass opacity in this lobe, compatible with pulmonary infarction (Figure 1). The final diagnosis was pulmonary infarction due to macroscopic fat embolism.

 
Fat embolism syndrome, defined as the release of fat into the systemic or pulmonary circulation, is rare. It usually occurs after long bone fracture, orthopedic surgery, or cosmetic procedures.(1) The majority of fat embolism cases are microscopic, presenting on CT as bilateral patchy or diffuse ground-glass opacities. Macroscopic fat embolism is a rare presentation of the disease in which macroscopic fat deposits are present in the pulmonary arteries. Its diagnosis is based on the demonstration of fat-attenuation filling defects in these arteries. Fat typically has negative attenuation values, enabling the distinction of fat embolism from pulmonary thromboembolism, characterized by positive attenuation values. This differentiation can have important implications for patient management.(1-3)
 
AUTHOR CONTRIBUTIONS
 
The authors equally contributed to this work.
 
CONFLICTS OF INTEREST
 
None declared.
 
REFERENCES
 
1.            Kaiser Ururahy Nunes Fonseca E, Chate RC. Macroscopic Fat Embolism after Cosmetic Surgery. Radiol Cardiothorac Imaging. 2022;4(2):e210316. https://doi.org/10.1148/ryct.210316
2.            Newbigin K, Souza CA, Torres C, Marchiori E, Gupta A, Inacio J, et al. Fat embolism syndrome: State-of-the-art review focused on pulmonary imaging findings. Respir Med. 2016;113:93-100. https://doi.org/10.1016/j.rmed.2016.01.018
3.            Murphy R, Murray RA, O’hEireamhoin S, Murray JG. CT pulmonary arteriogram diag-nosis of macroscopic fat embolism to the lung. Radiol Case Rep. 2024;19(5):2062-2066. https://doi.org/10.1016/j.radcr.2024.02.062