A 46-year-old woman with a history of portal vein and bile duct injury during cholecystectomy reported hematemesis, melena, and syncope. A previous endoscopy showed fine and medium esophageal varices. She was hospitalized with massive melena. A new endoscopy was performed, and hemostasis of bleeding was carried out using cyanoacrylate. The patient achieved clinical stability. Subsequently, the patient developed dyspnea and desaturation. A chest CT showed hyperdense material in structures, such as the gastric fundus, which is compatible with hemostasis material. Chest CT angiography showed hyperdense material in the segmental branch of the middle lobe and in the medial basal subsegmental branch of the right lower lobe, leading to partial filling failure, which is compatible with cyanoacrylate embolization.
Treatment of variceal bleeding with cyanoacrylate in endoscopy is effective in patients with liver disease and can reduce the size of varices on the first application. (1) However, this procedure can be complicated by embolization of the resulting polymer in some vessels, such as pulmonary arteries,(1) especially in patients with large varicose veins that require larger volumes of sclerosing agent.(2) Embolization appears to be more common in patients who received a greater volume of this agent.(3) Treatment for cyanoacrylate pulmonary embolism is mainly supportive.(2)
AUTHOR CONTRIBUTIONS CAQ: data collection, writing, descriptive analysis, and translation. PHRF: data collection, writing, descriptive analysis, and translation. DLG: data collection. All authors approved the final version of the manuscript.
CONFLICTS OF INTEREST None declared.
REFERENCES 1. Frassei JDS, Franco CS, Brambilla VR, Loureiro BMC, Kiebert CDS, Fonseca EKUN, et al. Cyanoacrylate pulmonary embolism after endoscopic sclerotherapy of gastric varices. Einstein (Sao Paulo). 2021;19:eAI5778. https://doi.org/10.31744/einstein_journal/2021AI5778
2. Michael PG, Antoniades G, Staicu A, Seedat S. Pulmonary Glue Embolism: An unusual complication following endoscopic sclerotherapy for gastric varices. Sultan Qaboos Univ Med J. 2018;18(2):e231-e235. https://doi.org/10.18295/squmj.2018.18.02.020
3. Habib SF, Muhammad R, Koulaouzidis A, Gasem J. Pulmonary embolism after scle-rotherapy treatment of bleeding varices. Ann Hepatol. 2008;7(1):91-93.