1 - Portuguese Journal of Pulmonology and Brazilian Journal of Pulmonology-

Revista Portuguesa de Pneumologia e Jornal Brasileiro de Pneumologia - 'Aquele Abraço'

António Morais, Carlos Robalo Cordeiro

J Bras Pneumol.2014;40(6):589-590

Original Article

2 - Gender differences in the perception of asthma and respiratory symptoms in a population sample of asthma patients in four Brazilian cities

Diferenças entre os sexos na percepção de asma e sintomas respiratórios em uma amostra populacional em quatro cidades brasileiras

Laura Russo Zillmer, Mariana Rodrigues Gazzotti, Oliver Augusto Nascimento, Federico Montealegre, James Fish, José Roberto Jardim

J Bras Pneumol.2014;40(6):591-598

3 - Efficacy and safety of the single-capsule combination of fluticasone/formoterol in patients with persistent asthma: a non-inferiority trial

Eficácia e segurança da associação fluticasona/formoterol em cápsula única em pacientes com asma persistente: estudo de não inferioridade

Marti Antilla, Fábio Castro, Álvaro Cruz, Adalberto Rubin, Nelson Rosário, Rafael Stelmach

J Bras Pneumol.2014;40(6):599-608

Objective: Fluticasone and formoterol are effective in the treatment of asthma. When a corticosteroid alone fails to control asthma, combination therapy is the treatment of choice. The objective of this study was to compare the efficacy and safety of formulations containing budesonide/formoterol (BUD/FOR), fluticasone alone (FLU), and the single-capsule combination of fluticasone/formoterol (FLU/FOR) on lung function in patients with mild-to-moderate persistent asthma. Methods: This was a randomized, multicenter, open phase III trial conducted in Brazil. The primary efficacy analysis was the assessment of non-inferiority between FLU/FOR and BUD/FOR combinations regarding FEV1 (in L) at the final visit. The secondary analyses were PEF, level of asthma control, serum cortisol levels, frequency of adverse events, adherence to treatment, and appropriate inhaler use. Results: We randomized 243 patients to three groups: FLU/FOR (n = 79), BUD/FOR (n = 83), and FLU (n = 81). In terms of the mean FEV1 after 12 weeks of treatment, the difference between the FLU/FOR and BUD/FOR groups was 0.22 L (95% CI: −0.06 to 0.49), whereas the difference between the FLU/FOR and FLU groups was 0.26 L (95% CI: −0.002 to 0.52). Non-inferiority was demonstrated by the difference between the lower limits of the two 95% CIs (−0.06 vs. −0.002). The level of asthma control and PEF were significantly greater in the FLU/FOR and BUD/FOR groups than in the FLU group. There were no significant differences among the groups regarding patient adherence, patient inhaler use, or safety profile of the formulations. Conclusions: The single-capsule combination of FLU/FOR showed non-inferiority to the BUD/FOR and FLU formulations regarding efficacy and safety, making it a new treatment option for persistent asthma. (ClinicalTrials.gov Identifier:NCT01202084 [http://www.clinicaltrials.gov/])

Keywords: Asthma; Steroids; Bronchodilator agents; Administration, inhalation.

4 - Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension

Disfunção ventricular esquerda em pacientes com suspeita de hipertensão arterial pulmonar

Francisca Gavilanes, José Leonidas Alves Jr, Caio Fernandes, Luis Felipe Lopes Prada, Carlos Viana Poyares Jardim, Luciana Tamie Kato Morinaga, Bruno Arantes Dias, Susana Hoette, Rogerio Souza

J Bras Pneumol.2014;40(6):609-616

5 - Epidemiological aspects of and risk factors for wheezing in the first year of life

Aspectos epidemiológicos e fatores de risco para sibilância no primeiro ano de vida

Hamilton Rosendo Fogaça, Fernando Augusto de Lima Marson, Adyléia Aparecida Dalbo Contrera Toro, Dirceu Solé, José Dirceu Ribeiro

J Bras Pneumol.2014;40(6):617-625

6 - Effects of home-based respiratory muscle training in children and adolescents with chronic lung disease

Efeitos do treinamento muscular respiratório domiciliar em crianças e adolescentes com doença pulmonar crônica

Iván Rodríguez, Daniel Zenteno, Carlos Manterola

J Bras Pneumol.2014;40(6):626-633

7 - Correlates of experimentation with smoking and current cigarette consumption among adolescents

Correlatos de experimentação e consumo atual de cigarros entre adolescentes

Amanda Gimenes Bonilha, Antonio Ruffino-Netto, Mayara Piani Sicchieri, Jorge Alberto Achcar, Antonio Luiz Rodrigues-Júnior, José Baddini-Martinez

J Bras Pneumol.2014;40(6):634-642

Objective: The aim of this study was to analyze social characteristics and stress as correlates of cigarette smoking in adolescence. The main intent was to identify elements that distinguish adolescents who had experimented with smoking and did not progress to regular smoking from those who became current smokers. Methods: Students at 10 high schools in the city of Ribeirão Preto, Brazil, completed a questionnaire based on an instrument employed in a similar large-scale study. The students were classified as never-smokers or experimenters. The experimenters were subcategorized as having become current smokers or nonprogressors. Analyses were performed using adjusted logistic models. Results: A total of 2,014 students (mean age, 16.2  1.1 years; females, 53%) completed the questionnaire. We categorized 1,283 students (63.7%) as never-smokers, 244 (12.1%) as current smokers, and 487 (24.2%) as nonprogressors. We found that experimentation with smoking was associated with being held back a grade in school (OR = 1.80), alcohol intake (low/occasional, OR = 8.92; high/regular, OR = 2.64), illicit drug use (OR = 9.32), having a sibling or cousin who smokes (OR = 1.39), having a friend who smokes (OR = 2.08), and high levels of stress (in females only, OR = 1.32). Factors associated with an increased risk of transitioning from experimenter to current smoker were alcohol intake (low/occasional, OR = 3.28; high/regular, OR = 2.16), illicit drug use (OR = 3.61), and having a friend who smokes (OR = 7.20). Conclusions: Current smoking was associated with a profile of socioeconomic correlates different from that associated with experimentation only. Our data (showing that current smoking was associated with having a friend who smokes, alcohol intake, and illicit drug use) suggest the need for comprehensive approaches to discourage substance use during adolescence.

Keywords: Smoking; Tobacco use; Adolescent behavior; Stress, psychological.

8 - Quantitative culture of endotracheal aspirate and BAL fluid samples in the management of patients with ventilator-associated pneumonia: a randomized clinical trial

Cultura quantitativa de amostras de aspirado endotraqueal e lavado broncoalveolar no manejo de pacientes com pneumonia associada à ventilação mecânica: um ensaio clínico randomizado

Ricardo de Amorim Corrêa, Carlos Michel Luna, José Carlos Fernandez Versiani dos Anjos, Eurípedes Alvarenga Barbosa, Cláudia Juliana de Rezende, Adriano Pereira Rezende, Fernando Henrique Pereira, Manoel Otávio da Costa Rocha

J Bras Pneumol.2014;40(6):643-651

9 - Facial pressure zones of an oronasal interface for noninvasive ventilation: a computer model analysis

Pontos de tensão de uma interface oronasal para ventilação não invasiva: uma análise através de um modelo computacional

Luana Souto Barros, Pedro Talaia, Marta Drummond, Renato Natal-Jorge

J Bras Pneumol.2014;40(6):652-657

Review Article

10 - Impact of the type of mask on the effectiveness of and adherence to continuous positive airway pressure treatment for obstructive sleep apnea

O impacto do tipo de máscara na eficácia e na adesão ao tratamento com pressão positiva contínua nas vias aéreas da apneia obstrutiva do sono

Rafaela Garcia Santos de Andrade, Vivien Schmeling Piccin, Juliana Araújo Nascimento, Fernanda Madeiro Leite Viana, Pedro Rodrigues Genta, Geraldo Lorenzi-Filho

J Bras Pneumol.2014;40(6):658-668