ABSTRACT

Objective: To develop reference equations for the Glittre Activities of Daily Living test (Glittre ADL-test) on the basis of anthropometric and demographic variables in apparently healthy individuals. A secondary objective was to determine the reliability of the equations in a sample of COPD patients. Methods: This was a cross-sectional study including 190 apparently healthy individuals (95 males; median age, 54.5 years [range, 42-65]; median FEV1 = 97% [range, 91-105.2]; and median FVC = 96% [range, 88.5-102]) recruited from the general community and 74 COPD patients (55 males; mean age, 65 ± 8 years; body mass index [BMI] = 25.9 ± 4.7 kg/m2; FEV1 = 36.1 ± 14.1%; and FVC = 62.7 ± 16.1%) recruited from a pulmonary rehabilitation center. Results: The mean time to complete the Glittre ADL-test was 2.84 ± 0.45 min. In the stepwise multiple linear regression analysis, age and height were selected as Glittre ADL-test performance predictors, explaining 32.1% (p < 0.01) of the total variance. Equation 1 was as follows: Glittre ADL-testpredicted = 3.049 + (0.015 × ageyears) + (−0.006 × heightcm). Equation 2 included age and BMI and explained 32.3% of the variance in the test, the equation being as follows: Glittre ADL-testpredicted = 1.558 + (0.018 × BMI) + (0.016 × ageyears). Conclusions: The reference equations for the time to complete the Glittre ADL-test were based on age, BMI, and height as independent variables and can be useful for predicting the performance of adult individuals. The predicted values appear to be reliable when applied to COPD patients.

Keywords: Activities of daily living; Exercise test; Reference values.

RESUMO

Objetivo: Elaborar equações de referência para o teste Glittre Activities of Daily Living (Glittre ADL) com base em variáveis antropométricas e demográficas em indivíduos aparentemente saudáveis. O objetivo secundário foi determinar a confiabilidade das equações em uma amostra composta por pacientes com DPOC. Métodos: Estudo transversal com 190 indivíduos aparentemente saudáveis [95 homens; mediana de idade: 54,5 anos (variação: 42-65); mediana de VEF1 = 97% (variação: 91-105,2); mediana de CVF = 96% (variação: 88,5-102)] recrutados na comunidade geral e 74 pacientes com DPOC [55 homens; média de idade: 65 ± 8 anos; índice de massa corporal (IMC) = 25,9 ± 4,7 kg/m2; VEF1 = 36,1 ± 14,1%; CVF = 62,7 ± 16,1%] recrutados em um centro de reabilitação pulmonar. Resultados: A média do tempo necessário para completar o teste Glittre ADL foi de 2,84 ± 0,45 min. Na análise de regressão linear múltipla passo a passo (stepwise), a idade e a estatura foram selecionadas como preditores do desempenho no teste Glittre ADL, explicando 32,1% (p < 0,01) da variância total. A equação 1 foi a seguinte: Glittre ADLprevisto = 3,049 + (0,015 × idadeanos) + (−0,006 × alturacm). A equação 2 incluiu idade e IMC e explicou 32,3% da variância do teste: Glittre ADLprevisto = 1,558 + (0,018 × IMC) + (0,016 × idadeanos). Conclusões: As equações de referência para o tempo necessário para completar o teste Glittre ADL basearam-se na idade, IMC e estatura como variáveis independentes e podem ser úteis para prever o desempenho de indivíduos adultos. Os valores previstos são aparentemente confiáveis quando aplicados em pacientes com DPOC.

Palavras-chave: Atividades cotidianas; Teste de esforço; Valores de referência.

INTRODUCTION

Reference equations for tests that measure functional capacity are essential for interpreting functional test results, assisting in quantifying the impairment of activities of daily living (ADL) and therapeutic response. Functional status is a multidimensional concept that characterizes the ability that a person has to provide for the necessities of life.(1) Factors such as aging,(2) obesity,(3) and chronic disease,(4) such as COPD, can negatively affect patient functional status. Exercise and ADL limitations are common manifestations in patients with COPD, increasing morbidity and mortality.(5) To evaluate the functional status of COPD patients, Skumlien et al.(6) developed the Glittre ADL-test, which is a standardized set of ADL-like activities known to be difficult for COPD patients. The Glittre ADL-test consists of multiple tasks that require upper and lower limb muscle activity during walking, rising from the seated position, stair climbing/descending, crouching, kneeling, carrying objects, and lifting objects.(6,7)

The Glittre ADL-test is an easily administered, valid, and reliable tool to measure functional status(7) in patients with stable COPD,(6,8,9) exacerbated COPD,(10) heart failure,(11) or community-acquired pneumonia/other respiratory diseases,(10) as well as in obese patients and post-bariatric surgery patients.(12) In addition, the Glittre ADL-test can differentiate between the functional status of healthy individuals and that of patients with COPD.(8) Furthermore, the time to complete the Glittre ADL-test has been shown to correlate with walking and sitting time in COPD patients, as well as with other ADL.(13) Similar physiological responses were found between the Glittre ADL-test and the six-minute walk test (6MWT), oxygen uptake being slightly higher during the Glittre ADL-test.(9)

Given that the factors that influence patient performance on the Glittre ADL-test have yet to be determined,(7) there are currently no reference equations to predict patient functional status on the basis of anthropometric and demographic data. Therefore, the objective of the present study was to investigate the influence of the aforementioned variables on patient performance on the Glittre ADL-test in order to generate reference equations for healthy individuals in the 20- to 80-year age bracket. A secondary objective was to determine the reliability of the equations in a sample of patients with COPD.

METHODS

Participants

Apparently healthy individuals were selected from among those living in the city of Florianópolis, Brazil. The inclusion criteria were as follows: being in the 20- to 80-year age bracket and being clinically stable (i.e., having had no severe or unstable disease in the six weeks prior to the study). The exclusion criteria were as follows: post-bronchodilator FEV1 and FVC < 80% of the predicted value; post-bronchodilator FEV1/FVC < 0.7; body mass index (BMI) < 18.5 kg/m2 or > 40 kg/m2; active smoking in the six months prior to the study; high physical activity level; and inability to understand or perform any of the tested activities. Of the 223 apparently healthy individuals who were selected to participate, 33 were excluded, 190 having therefore remained in the study.

In order to determine the reliability of the reference equations, 74 COPD patients were selected from among those treated at the Santa Catarina State University Treatment, Education, and Research Center for Pulmonary Rehabilitation, located in the city of Florianópolis, Brazil. Patients ≥ 40 years of age with Global Initiative for Chronic Obstructive Lung Disease stage II-IV COPD,(5) a smoking history ≥ 20 pack-years, and clinical stability in the four weeks prior to the study were included in the study. The exclusion criteria were as follows: long-term oxygen therapy, current smoking, lung diseases other than COPD, and comorbidities affecting patient ability to perform any of the tested activities.

Study protocol

Participants were asked questions regarding their medical history, medication use, and smoking history. Patient weight (in kg) and height (in cm) were measured with a digital scale (Tanita Corporation, Tokyo, Japan) and a portable stadiometer (Sanny; American Medical do Brasil Ltda., São Bernardo do Campo, Brazil), respectively, and the BMI was calculated by the formula weight/height2 (kg/m2). Lung function was assessed with an EasyOne® spirometer (ndd Medical Technologies, Andover, MA, USA), in accordance with the methods and criteria recommended by the American Thoracic Society and the European Respiratory Society,(14) predicted values being calculated.(15)

Participants performed the Glittre ADL-test twice, with a 30-min interval between tests. The shorter of the two tests was selected for data analysis. In individuals in the 20- to 59-year age bracket and in those in the 60- to 80-year age bracket the level of physical activity was measured by the short form of the International Physical Activity Questionnaire(16) and the version that has been adapted for use in Brazilian elderly individuals,(17) respectively.

The group of COPD patients underwent anthropometric measurements, pulmonary function testing, the Glittre ADL-test, and the 6MWT.
The 6MWT was performed indoors along a flat, straight, 20-m corridor, in accordance with the American Thoracic Society guidelines.(18,19) The percent predicted six-minute walk distance (6MWD) was calculated on the basis of an equation developed by Britto et al.(20)

All participants gave written informed consent. The study was approved by the Research Ethics Committee of the Santa Catarina State University (Protocol no. 225/2011).

Glittre ADL-test

The Glittre ADL-test was performed as described by Skumlien et al.(6) and comprises the following tasks: walking along a flat surface; stair climbing and descending; moving objects from one shelf to another (as well as putting them on the floor and back on the shelves); and rising from and sitting in a chair. Female participants carried a backpack weighing 2.5 kg, whereas male participants carried a backpack weighing 5.0 kg.(6) Heart rate, pulse oximetry, dyspnea (modified Borg scale),(21) and blood pressure were measured.

Statistical analysis

Statistical analysis was performed with the IBM SPSS Statistics software package, version 20.0 (IBM Corporation, Armonk, NY, USA) and the GraphPad Prism software, version 5.0 (GraphPad Inc., San Diego, CA, USA). The sample size required to generate a reference equation for healthy individuals in the 20- to 80-year age bracket was calculated by the following formula:
N > 50 + 8m where m is the number of independent variables.(22)

For five independent variables based on the theoretical assumptions (gender, age, height, weight, and BMI),(20,23 28) the minimum sample size was calculated to be 90. Given that the study sample comprised individuals in the 20- to 80-year age bracket, it was divided into six age groups (20-29 years; 30-39 years; 40-49 years; 50-59 years; 60-69 years; and 70-80 years), each of which comprised at least 14 individuals. The sample size required to maintain a balance between the genders was calculated to be 190.

Data were expressed as mean ± standard deviation or median (95% CI). The normality of the data was verified with the Kolmogorov-Smirnov test. Comparisons were performed with the Wilcoxon test, the Mann-Whitney test, or the independent sample t-test.

The association between the time to complete the Glittre ADL-test and the independent variables was tested by simple linear regression analysis. Stepwise multiple linear regression analysis was used in order to evaluate independent variables explaining the variance in the Glittre ADL-test. The normality of the residuals was verified graphically (histogram and Q-Q plot), and multicollinearity was assessed by examining tolerance (1 − r2) and variance inflation factor (1/1 − r2).(29) Reliability was assessed by Spearman's correlation coefficient, linear regression analysis, and the intraclass correlation coefficient (ICC). In addition, a paired-sample t-test or the Wilcoxon test was used in order to compare the actual time to complete the Glittre ADL-test with the predicted value.(20,30) The age-predicted maximal heart rate was calculated by the following formula: 208 − 0.7*ageyears.(31) Bland-Altman plots(29,31) were used in order to evaluate the agreement between the actual time to complete the Glittre ADL-test and the predicted value.(30,32) The significance level was set at p = 0.05 for all analyses.

RESULTS

Of the 223 apparently healthy individuals who were selected to participate, 190 had normal lung function and completed the study (Table 1). Of those, 95 were male. A total of 33 individuals were excluded, for the following reasons: restrictive or obstructive lung disease, in 17; inability to understand or perform any of the tested activities, in 14; active smoking in the six months prior to the study, in 1; and high self-reported physical activity, in 1. Of the 190 apparently healthy participants, 152 (80%) were classified as physically active. In addition, 51.5% were nonsmokers and 30.5% were former smokers. Self-reported comorbidities included systemic hypertension (in 25%), metabolic disorders (in 14.9%), thyroid disorders (in 8.2%), stable cardiac disease (in 2.6%), and osteoporosis (in 1.3%).
 



A total of 151 participants (79.5%) performed better on the second Glittre ADL-test than on the first. There was a 0.16 reduction in the mean time to complete the second test in comparison with the first (0.21 min; p < 0.01), with a 5.3% learning effect. The best test was completed in 2.84 ± 0.45 min (2 min and 50 s). The shortest and longest tests were 1.92 min (1 min and 55 s) and 4.17 min (4 min and 10 s) in duration, respectively. The median time to complete the first test was 2.95 min (range, 2.95-3.09), i.e., 2 min and 57 s, and the median time to complete the second test was 2.82 min (range, 2.80-2.92), i.e., 2 min and 49 s (p < 0.01). With the exception of systolic blood pressure, there were no differences in physiological variables between the first and second tests (Table 2). An ICC of 0.95 (95% CI: 0.93-0.96; p < 0.01) was found between the time to complete the first test and the time to complete the second test. There was no significant difference between males and females regarding their performance on the Glittre ADL-test (p = 0.35).
 



The simple linear regression analysis showed that the performance on the Glittre ADL-test was significantly associated with age (R2 = 0.30; p < 0.01), height (R2 = 0.09; p < 0.01), and BMI (R2 = 0.05; p = 0.01) but not with weight or gender. In the stepwise multiple linear regression analysis, age and height were selected as Glittre ADL-test performance predictors, explaining 32.1% (p < 0.01) of the total variance. In addition, BMI and age explained 32.3% (p < 0.01) of the total variance when only participants with a BMI of < 35 kg/m2 were taken into account.

The reference equation for the Glittre ADL-test was as follows (R2 = 0.321):
Glittre ADL-testpredicted = 3.049 + (0.015 × ageyears) + (−0.006 × heightcm)

A second equation was generated by excluding the participants with a BMI ≥ 35 kg/m2 (R2 = 0.323):
Glittre ADL-testpredicted = 1.558 + (0.018 × BMI) + (0.016 × ageyears)

No multicollinearity was present (Table 3). The Bland-Altman plots showed good agreement between the actual time to complete the Glittre ADL-test and the predicted values in the group of healthy individuals (Figures 1A and C) but not in the group of patients with COPD (Figures 1B and D).
 

 





The reliability of the reference equations for the Glittre ADL-test was tested in 74 COPD patients (Table 1). An ICC of 0.97 (95% CI: 0.95-0.98; p < 0.01) was found between the time to complete the first test and the time to complete the second test. A strong correlation was found between the mean time to complete the Glittre ADL-test (4.70 ± 1.9 min; 147.4 ± 57.6% of the predicted value) and the mean 6MWD (435.1 ± 101.1 m; 78.4 ± 17.4% of the predicted value; r = −0.81; p < 0.01). In addition, a strong correlation was found between percent predicted values for equation 1 (r = −0.74; p < 0.01) and equation 2 (r = −0.86; p < 0.01; Figure 2), with a significant association between the two (equation 1: R2 = 0.51; equation 2: R2 = 0.65; p < 0.01). Significant differences were found between the actual performance on the Glittre ADL-test and the predicted values for the two equations (p < 0.05).
 



DISCUSSION

To our knowledge, this is the first study to establish reference equations for the Glittre ADL-test on the basis of how healthy individuals perform on the test. The mean time to complete the Glittre ADL-test was 2.84 min (2 min and 50 s). Among the independent variables, age and height were found to be significant independent predictors, explaining 32.1% of the variance in the Glittre ADL-test when individuals with a BMI of 18.5-40 kg/m2 were taken into account (equation 1). However, when individuals with a BMI ≥ 35 kg/m2 were excluded (equation 2), age and BMI accounted for 32.3% of the variance in the test.

Of the 190 healthy participants, 79.5% performed better on the second Glittre ADL-test. The learning effect was 5.3%, and the shortest test was 1.92 min (1 min and 55 s) in duration. Skumlien et al.(6) found that the shortest test among healthy individuals was 2 min in duration. However, the demographic and anthropometric characteristics of those individuals were not mentioned. In a previous study, our research group showed that healthy individuals in the 20- to 39-year age bracket completed the Glittre ADL-test in 2.62 ± 0.34 min (2 min and 37 s), the shortest test having lasted 2.03 min (2 min and 2 s), with a 6.3% learning effect.(33) Therefore, it is possible that individuals who complete the test in approximately 2 min have preserved functional capacity.

Anthropometric and demographic variables are usually helpful to determine individual performance on functional tests.(20,23-25) Therefore, we hypothesized that variables such as age, height, BMI, weight, and gender would be predictors of the time to complete the Glittre ADL-test.

Age was the only independent variable that remained in the two equations. Aging affects muscle mass, strength, resistance, balance, and coordination-all of which are components of functional capacity-leading to a progressive physical decline even in healthy physically active individuals.(34) In the present study, age was related to a longer time to complete the Glittre ADL-test. This might be due to tasks such as sitting in and rising from a chair, walking, crouching/kneeling, and stair climbing/descending. The ability to rise from a chair deteriorates with age; aging is a major source of disability and impaired autonomy, being highly associated with loss of quadriceps strength.(35) Age is also an important predictor of walking speed, being included as a variable in equations for several functional status tests, such as the 6MWT and the incremental shuttle walk test.(23,26,27,36,37) In addition to walking, individuals performing the Glittre ADL-test are required to crouch and kneel, which are activities that a quarter of older adults have difficulty in performing or are unable to perform; this is probably due to ankle plantar flexor and knee weakness, as well as to balance impairment.(38) Stair climbing and descending are also compromised in elderly individuals, because of reduced muscle strength, reduced balance, pain, fear of falling, and impaired sensation.(38)

In the second of the two equations generated in the present study, the BMI was the predictor with the highest coefficient. Previous studies have shown the influence of the BMI on patient performance on functional tests such as the 6MWT(20,27) and the incremental shuttle walk test.(23) In the present study, a higher BMI translated to a worse performance on the Glittre ADL-test. Obesity increases the workload for a given activity,(25) and body composition is significantly associated with walking speed and endurance,(39) as well as with walking performance and the ability to perform the sit-to-stand test without assistance.(35)

Although it could be argued that the inclusion of patients with a BMI ≥ 35 kg/m2 introduced a bias in the present study because reference values should be derived from normal individuals, a decision was made to include such patients in the model for equation 1 but exclude them from the model for equation 2. In a real-life scenario, health professionals habitually encounter chronic respiratory disease patients with class II or III obesity and should be able to calculate the predicted values for functional capacity tests in such patients. There is controversy in the literature regarding this issue, such patients having been excluded from some studies(24,25,40) but not from others. (20,23,26-28) Given that the two equations were found to have similar coefficients of determination and similar statistical properties, the choice between the two should be made on the basis of the BMI.

We had hypothesized that weight and height were predictors of a longer time to complete the Glittre ADL-test and a shorter time to complete the test, respectively. Overweight influences gait and increases the workload on horizontal and vertical displacements, which occur during the Glittre ADL-test tasks of walking, sitting/standing, stair climbing/descending, and crouching/kneeling.(41) However, weight was not retained in either equation.

Despite its low coefficient, height was considered to be an independent predictor of performance on the Glittre ADL-test, although only for equation 1. This might be due to the fact that the taller the person, the longer his or her legs and, consequently, the longer his or her stride, their walking therefore being more efficient(25) and contributing to a shorter time to complete the Glittre ADL-test.

Gender was found to have no influence on the time to complete the Glittre ADL-test, a finding that is consistent with those of other studies examining patient functional status.(23,24,27,28,33) The lack of association between gender and the time to complete the Glittre ADL-test might be partly explained by the lack of statistical difference between males and females regarding their performance on the test. In addition, it is possible that the heavier backpack carried by males influenced their performance and compensated for potential fitness differences between the genders. Although Skumlien et al.(6) had females carrying a backpack weighing 2.5 kg and males carrying a backpack weighing 5.0 kg, the impact of this additional weight on male performance on the Glittre ADL-test remains unclear.

Although the reliability of a reference equation is usually confirmed in healthy individuals, our equations were tested in COPD patients because the Glittre ADL-test was validated for use in and is primarily administered to such patients. In addition, the significance of the time to complete the Glittre ADL-test has yet to be established. Therefore, the 6MWD and its predicted value were selected to test the reliability of the derived equations, because the 6MWT and the Glittre ADL-test were designed to assess functional capacity and because the latter has been found to correlate strongly with the former in COPD patients.(6,9) In the present study, the predicted Glittre ADL-test value was strongly correlated with the percent predicted 6MWD, which was calculated on the basis of an equation developed by Britto et al.(20) The reference equations for the Glittre ADL-test were found to be reliable because they evidenced the impaired functional status of the patients with COPD, for whom the mean time to complete the test was approximately 45.2% longer than the expected maximum time to complete it. It could be argued that there is poor agreement between actual and predicted values for patients with COPD, especially those with worse functional impairment. However, the proposed equations are expected to underestimate the predicted values because it takes patients with COPD longer to complete the Glittre ADL-test than it does healthy individuals,(6,8,33) COPD patients therefore showing values > 100% of the predicted value. Therefore, the worse the functional impairment, the more the actual performance on the Glittre ADL-test will differ from the predicted value derived from apparently healthy individuals. This reinforces the fact that the Glittre ADL-test is better at differentiating between patients with severe functional limitations(6) and those with preserved functional capacity, given that it takes the latter group of patients almost the same time to complete the test as it does healthy individuals (i.e., approximately 3 min). As expected, poor agreement, moderate correlations, and significant differences were found between the actual performance on the Glittre ADL-test and the predicted value in the group of COPD patients investigated in the present study.

The present study has some limitations that should be noted. Although we calculated the required sample size for the study and attempted to maintain a balance between the genders and the numbers of individuals in each age group, ours was a convenience sample. Given that only approximately 32% of the variance in the time to complete the Glittre ADL-test was explained by the derived equations, it remains to be determined whether other factors, such as balance, peripheral muscle strength, behavior, cognition, and physiological factors, have any influence on the time to complete the test. However, it should be noted that studies aimed at generating reference equations for the 6MWT have shown a variance similar to that observed in the present study, having included independent variables similar to those included in the present study.(24,25,28,40) In order to prioritize clinical practice, we investigated the reliability of our reference equations in a group of COPD patients, in whom impaired functional capacity was evidenced by establishing a relationship between their performance on the Glittre ADL-test and their performance on the 6MWT and by comparing their performance on the Glittre ADL-test with that of healthy individuals. Therefore, future studies should investigate the reliability of the equations in healthy individuals.

In summary, the two equations generated in the present study can explain approximately 32% of the variance in the time to complete the Glittre ADL-test. The choice of equation for use depends on the BMI. The predicted values appear to be reliable when applied to patients with COPD.


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