The relationship between cancer and coagulopathy was suggested by Trousseau nearly 150 years ago. Later, it became more evident that
oncologic patients are at a higher risk of experiencing thromboembolic events. This can be due to activation of the coagulation system
either by neoplastic cells or by prescribed therapies (chemotherapy or surgical procedures). In fact, these events can constitute the first
manifestation of cancer, and their recurrence, despite efficient anticoagulation, has been described. The coagulation system is normally
activated in order to provide healing. In the presence of neoplasms, this complex system is activated as a response to multiple stimuli and
seems to contribute to cancer progression. Activation of the coagulation system has a greater effect on metastatic foci than on the primary
tumor. However, most cancer victims die from complications caused by metastasis, which underscores the importance of this theme. In
this area, various mechanisms have been described, creating promising perspectives for future treatments. The current success in using
low-molecular-weight heparins against small cell lung cancer is encouraging. Although the knowledge of those mechanisms is relatively
incipient, many basic research and clinical studies are underway.
Keywords: Lung neoplasms; Thrombophilia.